Monday, July 4

11 am

@ IECB auditorium

Dr. Tomohisa SAWADA

Laboratory for Chemistry and Life Science, Institute of Innovative Research

Tokyo Institute of Technology, Japan

Metal–peptide rings and nets with entangling topologies

Construction of topological molecules has long attracted chemists, yet synthetic strategies for highly complexed topologies remain unexplored to date. In this talk, our recent achievements by using metal–peptide strands will be introduced. Our folding-and-assembly strategy, based on a cooperative processes of peptide self-folding and metal-induced self-assembly, has shed light on the latent entangling nature of peptides and enabled advanced topological nanostructures. Remarkable examples such as torus knots, polyhedral links, and spherical nets will be discussed.

Host: Yann FERRAND

IECB Friday seminars 2022

March 18, 2022:

Dr. Kevin Macé (Birkbeck college, Institute of Structural and Molecular Biology, UK)

Title: Type 4 secretion system cryo-EM structures

March 31, 2022:

Dr. Fabienne Burlina (Laboratoire des Biomolécules, Sorbonne Université, Paris)

Title: Extending chemical ligation for the synthesis of proteins: application to NEMO ubiquitylation

Dr. Yung-Sing Wong (Département de pharmacologie moléculaire, Equipe Chémobiologie et outils moléculaires thérapeutiques, Université Grenoble-Alpes, Grenoble)

Title: Benefits of forming spatio-temporal chemical bonds in living environments

Dr. Leos Valasek (Institute of Microbiology of the Czech Academy of Sciences, Czech Republic)

Title: Longer is not always the best; lessons from the tRNA anticodon stem

IECB Friday seminars 2021

January 12, 2021:

Dr. Hervé Vezin (CNRS - Laboratoire Avancé de Spectroscopie pour les Interactions la Réactivité et l'Environnement (LASIRE), Université de Lille)

Title: Advanced EPR spectroscopy in material chemistry for batteries

February 5, 2021:

Dr. Hagen Hofmann (Department of Structural Biology, Weizmann Institute of Science)

Title: Allostery through DNA drives phenotype switching

March 5, 2021:

Prof. Camilo Perez (Biozentrum, University of Basel)

Title: Structure and mechanism of a proton dependent lipid transporter involved in lipoteichoic-acids biosynthesis

March 18, 2021:

Dr. Michael Eck (Dana-Farber Cancer Institute and Harvard Medical School)

Title: Insights into regulation of the Ras/Raf/MAPk pathway from Cryo-EM Structures of BRAF-MEK-14-3-3 Complexes

March 26, 2021:

Dr. Stephan Rauschenbach (University of Oxford)

Title: Electrospray ion beam deposition for single molecule imaging

April 2, 2021:

Prof. Bernard Rentier (Recteur Honoraire, Université de Liège)

Title: Open Science: Excellence revisited

April 15, 2021:

Dr. Nora Vazquez-Laslop (University of Illinois at Chicago)

Title: Macrolide antibiotics as modulators of translation

May 7, 2021:

Dr. Abhishek Chatterjee (Department of Chemistry, Boston College)

Title: Genetically encoded chemistries to read and write biology

May 28, 2021:

Dr. Julien Gronnier (Center for Plant Molecular Biology, University of Tübingen)

Title: Nanoscale regulation of cell-surface receptor signaling

June 3, 2021:

Dr. Jonathan Visentin (CHU de Bordeaux, Université de Bordeaux, Immuno ConcEpT, UMR CNRS 5164)

Title: Surface plasmon resonance to study anti-HLA antibodies: transfer of a basic science method to the bedside of organ transplant recipients and beyond

June 11, 2021:

Prof. Pierre Sonveaux & Prof. Raphaël Frédérick (Université catholique de Louvain)

Title: Discovery of an oxidative pathway of lactate in cancer and its druggability by inhibitors of lactate dehydrogenase 1 (LDH1) oligomerization

June 11, 2021:

Dr. Alexander Harms (Biozentrum, University of Basel)

Title: Drop out or go viral: A story of planned and unplanned expeditions into the phage world

June 25, 2021:

Dr. Eric Cornes (Institute Pasteur)

Title: Non-coding small RNAs as versatile regulators of germline gene expression programs

June 25, 2021:

Dr. Jacob Bobonis (EMBL Heidelberg)

Title: Bacterial retrons encode phage-sensing toxin/antitoxin systems

September 13, 2021:

Dr. Benoit Malleret (National University of Singapore)

Title: Molecular mechanisms of Plasmodium vivax invasion and cell tropism of zoonotic malaria species

September 22, 2021:

Prof. Valérie de Crécy-Lagard (University of Florida)

Title: Linking gene and function by comparative genomics: examples from deazapurine metabolism reveal cross-talks between RNA and DNA modifications

October 29, 2021:

Dr. Vishukumar Aimanianda (Institut Pasteur)

Title: Fungal cell-wall polysaccharides, exploiting their translational potential

November 26, 2021:

Dr. Niels Fischer (Max Planck Institute for Biophysical Chemistry, Germany)

Title: Single particle cryo-EM - Towards atomic-resolution of molecular machines in motion

Dr. Megan Wright (University of Leeds, UK)

Title: Chemical proteomic tools to study host-microbe interactions