Single-molecule spectroscopy of protein - nucleic acid interactions

We are interested in understanding the molecular mechanisms of interactions between intrinsically disordered proteins (IDPs) and nucleic acids.

For this purpose we use a large bouquet of state-of-the-art techniques, among which the central role is attributed to single-molecule spectroscopy in combination with Förster resonance energy transfer (single-molecule FRET), both in vitro and in live cells.